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Natural products provide the greatest untapped opportunity for drug discovery. We have built the tools to capture it.
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New Medicines
Nature’s chemistry has evolved under billions of years of selective pressure to modulate life’s fundamental phenomena. This has led to incredible diversity of chemical properties and biological activity. This diversity is uncharacteristic of traditional small molecule libraries and inaccessible to even cutting-edge library generation technologies. We’re harnessing this untapped potential to rapidly deliver new medicines, and hope, for complex diseases. Here’s how we do it.
New Modalities
Our chemistry provides a unique opportunity to access known and emerging modalities of tuning biology. We are rapidly identifying novel chemistry that degrades or stabilizes proteins by acting like a molecular glue, changes the shape of difficult-to-drug proteins allowing modulation of an undruggable target, or covalently inhibits specific proteins.
New Targets
Uncovering the biological basis of the effects of nature’s diverse chemistry is a powerful way to understand the basis of disease. Just as the study of rapamycin once led to the discovery of mTOR signaling, we have built technologies that rapidly uncover novel disease targets while simultaneously advancing these molecules as new medicines. Get in touch to learn more!
New Medicines
Nature’s chemistry has evolved under billions of years of selective pressure to modulate life’s fundamental phenomena. This has led to incredible diversity of chemical properties and biological activity. This diversity is uncharacteristic of traditional small molecule libraries and inaccessible to even cutting-edge library generation technologies. We’re harnessing this untapped potential to rapidly deliver new medicines, and hope, for complex diseases. Here’s how we do it.
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hits
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Lead
Identification
Desease
Validation
Lead
Optimization
Liver InflaMmation
2 Chemical Series
Neuroinflammation
5 Chemical Series
NF-kB / IL-1B signaling
29 Chemical series
NLRP3 inflammasome
1 Chemical series
Gut-restricted
fxr agonism
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1 Chemical series
Gut-restricted
tgr5 agonism
1 Chemical series
Nav 1.7
1 Chemical series
PCSK 9
6 Chemical series
Ind-
enabling
Indication
Nash, Wilson's disease
Parkinson’s disease, als
Acute liver failure, multiple
Multiple
NASH, PBC, IBD
Type ii diabetes
Pain
Hypercholestrolemia
New Targets
Uncovering the biological basis of the effects of nature’s diverse chemistry is a powerful way to understand the basis of disease itself. Just as the the study of Rapamycin once led to the discovery of mTOR signaling, we have built technologies that rapidly uncover novel disease targets. Get in touch to learn more!
Our Advantages
Biologically Relevant Library
Shaped by evolution
Unique Technology Platform
Solves well-understood historical challenges of bioactivity annotation, structure elucidation, and manufacturing
>10x greater hit rates
In a head-to-head comparison with multiple difficult targets
Prolific source of next-generation compounds
Molecular glues, and protein-protein interaction disruptors
Compatible across modalities:
Target-binding, target-activity, or phenotypic screening
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